Centrosome Surfeit
نویسندگان
چکیده
منابع مشابه
A Surfeit of Cycles
Chaotic sets are organized about “skeletons” of periodic orbits in the sense that every point on a chaotic set is arbitrarily close to such an orbit. The orbits have the stability property of saddles: attracting in some directions; repelling in others. This topology has implications for changing climates that evidence pronounced variability on time scales ranging from decades to tens of thousan...
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Human NDR kinases are upregulated in some cancer types, yet their functions still remain undefined. Here, we report the first known function of a mammalian NDR kinase by demonstrating that human NDR directly contributes to centrosome duplication. A subpopulation of endogenous NDR localizes to centrosomes in a cell-cycle-dependent manner. Overexpression of NDR resulted in centrosome overduplicat...
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All cells are polar. This is particularly evident in eukaryotic cells, where an organized cytoskeleton is used to differentiate parts of the cell. Microtubules — an important part of this cytoskeleton — are especially well suited to playing a part in cell polarity because of their own intrinsic polarity. And the centrosome, the unique organelle that organizes microtubules into useful arrays, is...
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D epending on the position of the mitotic spindle, a dividing cell can split evenly or unevenly, lengthwise or down the middle. As a graduate student at the MRC Laboratory of Molecular Biology in Cambridge, England, Anthony Hyman showed how the centrosomes' travels set up the division axis in Caenorhabditis elegans (Hyman and White, 1987). Hyman was rummaging through the literature when he stum...
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ژورنال
عنوان ژورنال: Science
سال: 2013
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.340.6140.1500-d